Atmospheric Interactions and Cardiac Arrhythmias

Although plausible pathophysiological mechanisms link air pollution to arrhythmo­ genesis, among them altered autonomic tone, repolarization abnormalities, oxidative stress, myocardial ischemia, and increased intracardiac pressure (Link and Dockery 2010), definitive conclusions have not been reached as yet. Langrish et al. (2014) analyzed 13 double­blind randomized crossover studies and found no significant risk of arrhythmia attributable to acute controlled exposure to air pollutants. Three issues related to meteo­ rological factors probably either confound or modify the short­term association between air pollution and cardiac arrhythmia. First, several meteorological elements, including air temperature, atmospheric pres­ sure, relative air moisture, and wind speed and direction, also are implicated in trigger­ ing ventricular (Čulić et al. 2004, 2005) and supraventricular (Čulić et al. 2012, 2013) arrhythmias independent of physical and emotional stress. In the short term, those meteorological factors may facilitate arrhyth­ mias in susceptible patients by increasing circulatory load and thromboinflammatory processes (Čulić 2014). Second, these same meteorological ele­ ments substantially influence concentrations of sulfur dioxide, carbon monoxide, nitro­ gen dioxide, ozone, and suspended particulate matter (Bertaccini et al. 2012; Ilten and Selici 2008; Ito et al. 2007). In addition, the greatest ozone production and pollution results from stable, dry, hot weather with high atmospheric pressure and low wind (Vanos et al. 2014). Air pollution may increase human vul­ nerability to the effects of temperature, and temperature extremes, in turn, influence population vulnerability to air pollution (Burkart et al. 2013; Ren et al. 2006). Vanos et al. (2014) reported that cardiovas­ cular and respiratory mortality due to short­ term exposure to gaseous air pollutants was significantly modified by weather types and season. Alberdi et al. (1998) reported that both relative air moisture and air temperature are strongly related to daily mortality even after controlling for air pollution and influ­ enza. Keatinge and Donaldson (2001) sug­ gested that prolonged cold weather with less wind and rain may produce false associations between mortality and certain air pollutants. Finally, strong mutual interrelations exist among the above­mentioned meteorological elements. Alberdi et al. (1998) pointed out the strong inverse association they observed between relative air moisture and air temperature as an important problem for regression analysis. Langrish et al. (2014) caution against definitive acceptance of air pollution as an independent trigger of cardiac arrhythmias. However, the studies included in their analysis had no data on meteorological factors. It is likely that interactive effects among air pol­ lutants and meteorological elements bias each other’s association with arrhythmias and other acute cardiac events. Therefore, further research of the health effects of atmospheric factors should continue in order to identify poten­ tially harmful influences for the population as whole as well as for its vulnerable subgroups. The author declares he has no actual or potential competing financial interests.